The project aims to develop a comprehensive and accurate model of cardiovascular physiology, including a model of cardiac contraction and filling, to study the effect of regional changes in aortic stiffness on cardiac function. The heart model will incorporate a physical-based representation of blood flow dynamics within the major coronary arteries, accounting for fluctuations in peripheral vascular resistance resulting from left ventricular contraction and filling, which respectively squeeze and expand the coronary arterial network. By integrating these factors, the model will provide insights into the intricate interplay between aortic characteristics and cardiac performance across various age groups. This work forms part of a multi-disciplinary translational research programme and the student will be paired with a clinical research fellow, who will acquire and work with complimentary clinical data, ensuring the research informs patient care at the earliest opportunity.
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Computational assessment of the effect of endovascular aortic repair on cardiac function
