This project aims to develop a diffuse correlation spectroscopy (DCS) sensing device to monitor ultrasound intervention continuously during focused ultrasound therapy operations. Despite the promise of ultrasound-based non-invasive neuromodulation and targeted drug delivery in neurological disorders, real-time monitoring of cerebral hemodynamics during these procedures remains challenging, limiting treatment optimization and increasing the risk of complications. As ultrasound modulation mechanically affects local vasculature, DCS, a non-invasive optical technique providing real-time information on microvascular blood flow dynamics, shows potential for intraoperative monitoring of ultrasound brain modulation. This project will investigate the use of DCS in monitoring ultrasound intervention. The DCS performance in deep tissues will be enhanced by combining it with holographic light characterisation, which will enable the developed device to effectively monitor blood flow in the deep brain. We will systematically evaluate the device’s efficacy using phantoms and in vivo mouse models.
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Deep tissue diffuse correlation spectroscopy for monitoring transcranial ultrasound interventions
