Available

Project reference

2024_P19_Bergholt_Shangaris

Start date

June or October 2025
4

Back to projects

Development of novel widefield imaging modalities for enhancing intervention in twin-to-twin transfusion syndrome

Twin-to-Twin Transfusion Syndrome (TTTS) is a rare yet potentially life-threatening condition occurring in pregnancies where identical twins share a placenta and blood vessels. Despite advances in laparoscopy and intervention techniques, TTTS remains challenging to manage due to limitations in laparoscopic imaging caused by the poor quality of images through amniotic fluid. The primary objective of this project is to develop a novel laparoscopic imaging method for wide-field monitoring and visualization of vessels amidst diffuse turbid light scattering in amniotic fluid. We aim to create a high-contrast imaging technique that provides label-free, high-contrast widefield visualization of blood vessels in TTTS through amniotic fluid. This will involve understanding light propagation in scattering fluid, employing artificial intelligence-enabled imaging processing for image enhancement, and developing innovative label-free contrast mechanisms utilizing polarized near-infrared imaging and sensitive detection methods.