Precision guidance for deep brain stimulation surgery via patient-specific structural connectivity mapping using ultra high field MRI

Deep brain stimulation (DBS) is a surgical procedure involving implantation of electrodes into the brain, then application of current to stimulate specific structures. DBS has become a mainstay of treatment for movement disorders such as Parkinson’s disease and Essential Tremor and is increasingly now applied in in childhood. Success in all age groups hinges on the accurate targeting of brain structures. Traditional imaging techniques often lack the resolution required or specificity to delineate the small, complex regions involved. This project seeks to provide unprecedented visualization of deep brain anatomy and connectivity by using ultrahigh field (UHF) MRI. UHF offers high resolution and strong contrast but suffers from image distortion: when images are to be used for surgical guidance with submillimetre precision, these distortions can adversely affect the surgical outcome. Our aim is to properly characterise distortions and develop robust and simple methods to correct for them.